Report Generator Skill
Generate professional drug discovery intelligence reports.
Quick Start
code
/dossier EGFR --format pdf /brief EGFR competitors --format ppt /gng project-KRAS --full /report --template competitor-brief Generate a Go/No-Go report for HER2 inhibitor project
What's Included
| Report Type | Description | Use Case |
|---|---|---|
| Target Dossier | Comprehensive target analysis | Target validation meetings |
| Competitor Brief | Competitive intelligence summary | Portfolio reviews |
| Go/No-Go | Decision support with scoring | Investment decisions |
| Weekly Update | Weekly intelligence summary | Team updates |
| Project Overview | Full project analysis | Stakeholder reports |
Report Types
1. Target Dossier (/dossier)
Comprehensive target analysis for validation decisions.
Sections:
- •Executive Summary (1 page)
- •Target Overview
- •Druggability Assessment
- •Disease Associations
- •Competitive Landscape
- •Safety Assessment
- •Opportunities & Risks
- •Recommendations
Output: PDF (10-15 pages)
code
/dossier EGFR /target-dossier KRAS G12C --format pdf Generate dossier for BRAF V600E
2. Competitor Brief (/brief)
Competitive intelligence summary for portfolio reviews.
Sections:
- •Market Overview
- •Approved Products
- •Pipeline Analysis
- •Company Landscape
- •Key Differentiators
- •White Space
Output: PPT (8-12 slides)
code
/brief EGFR inhibitors /competitor-brief GLP-1 agonists --format ppt Create competitor brief for obesity market
3. Go/No-Go Analysis (/gng)
Decision support with multi-dimensional scoring.
Scoring Dimensions:
| Dimension | Weight | Assessment Criteria |
|---|---|---|
| Scientific Rationale | 25% | Target validation, disease linkage strength |
| Differentiation | 20% | Competitive advantage, novelty |
| Feasibility | 20% | Technical feasibility, developability |
| Commercial | 20% | Market size, unmet need, pricing |
| IP/Safety | 15% | Patentability, safety risk |
Score Interpretation:
- •80-100: Strong Go - Proceed with confidence
- •60-79: Go with conditions - Address specific concerns
- •40-59: Caution - Significant concerns, re-evaluate
- •0-39: No-Go - Do not proceed
Output: PDF with scorecard (5-8 pages)
code
/gng project-EGFR-4thgen /go-no-go KRAS inhibitor --full Generate Go/No-Go analysis for ADC program
4. Weekly Update (/weekly)
Weekly intelligence summary for team alignment.
Sections:
- •Key Developments
- •Literature Highlights
- •Pipeline Updates
- •Conference Abstracts
- •Deals & News
Output: Email/Markdown (1-2 pages)
code
/weekly --targets EGFR,KRAS,HER2 /weekly-update --diseases NSCLC,CRC Generate weekly report for oncology portfolio
5. Project Overview (/report --full)
Complete analysis combining all above sections.
Output: Full report (30-50 pages)
code
/report --full EGFR program /generate full project report for KRAS G12C
Output Formats
| Format | Description | Use Case |
|---|---|---|
| Markdown | Default, fully formatted | Quick review, version control |
| Professional report | Meetings, archives | |
| PPT | Slide deck | Presentations |
| One-pager | Single page summary | Executive updates |
Go/No-Go Scoring Example
markdown
# Go/No-Go Analysis: KRAS G12C Inhibitor Project ## Overall Score: 72/100 (Go with Conditions) ### Dimension Scores | Dimension | Score | Weight | Weighted | Status | |-----------|-------|--------|----------|--------| | Scientific Rationale | 85/100 | 25% | 21.25 | ✅ Strong | | Differentiation | 65/100 | 20% | 13.00 | ⚠️ Moderate | | Feasibility | 75/100 | 20% | 15.00 | ✅ Good | | Commercial | 80/100 | 20% | 16.00 | ✅ Strong | | IP/Safety | 50/100 | 15% | 7.50 | ⚠️ Concern | ### Detailed Assessment #### Scientific Rationale (85/100) ✅ **Strengths:** - KRAS G12C validated in NSCLC, CRC - Strong genetic association - Clear mechanism of action **Score:** 85/100 #### Differentiation (65/100) ⚠️ **Strengths:** - First-in-class opportunity - Novel covalent binding **Concerns:** - 4 competitors in Phase II/III - Amgen and Mirati ahead **Score:** 65/100 #### Feasibility (75/100) ✅ **Strengths:** - Proven chemistry platform - Clear PK/PD biomarkers **Concerns:** - Resistance mutations observed - Combination complexity **Score:** 75/100 #### Commercial (80/100) ✅ **Strengths:** - Large NSCLC market - Premium pricing potential - Expansion to CRC, pancreatic **Score:** 80/100 #### IP/Safety (50/100) ⚠️ **Concerns:** - Patent landscape crowded - Off-target toxicity risks - Sotorasib safety signals **Score:** 50/100 ### Conditions to Proceed 1. **IP:** Conduct FTO analysis, explore novel binding pocket 2. **Safety:** Early toxicity profiling, off-target screening 3. **Differentiation:** Focus on combination strategies, CNS penetration ### Recommendation **PROCEED with Conditions** - Strong scientific and commercial rationale, but address IP position and safety profile before major investment.
Examples
Target Dossier
code
/dossier EGFR Generate a target dossier for HER2 /target-dossier KRAS --focus safety
Competitor Brief
code
/brief EGFR TKIs Create competitor brief for obesity drugs /competitor-brief GLP-1 --format ppt --include-privates
Go/No-Go
code
/gng my-project-name /go-no-go KRAS G12C --full Generate decision report for ADC platform
Weekly Update
code
/weekly /weekly-update --targets EGFR,KRAS --format email
Custom Report
code
/report --template custom --sections exec-sum,market,competition /generate report using template project-overview
Running Scripts
bash
# Generate dossier python scripts/generate_dossier.py EGFR --format pdf --output reports/ # Generate brief python scripts/generate_brief.py "EGFR inhibitors" --format ppt # Go/No-Go with custom weights python scripts/generate_gng.py project-name --weights science=30,diff=15 # Weekly report python scripts/weekly_report.py --targets EGFR,KRAS,HER2 --format email
Requirements
For PDF/PPT generation:
bash
pip install weasyprint python-pptx jinja2 pandas
Additional Resources
Best Practices
- •Specify format: Always include output format
- •Use templates: Reference existing templates for consistency
- •Include context: Add project-specific considerations
- •Review scores: Validate Go/No-Go assumptions
- •Version control: Track report iterations
Report Templates
Templates are in templates/ directory:
code
templates/ ├── target-dossier.md # Target validation report ├── competitor-brief.md # Competitive intelligence ├── go-no-go.md # Decision support ├── weekly-update.md # Weekly intelligence └── project-overview.md # Full project analysis
Common Pitfalls
| Pitfall | Solution |
|---|---|
| Missing context | Include project background |
| Generic scores | Customize weights by project |
| Outdated data | Always refresh data before report |
| Too long | Use executive summary |
| Wrong format | Verify format before generation |